Understanding how healthy plant fats might help slow breast cancer growth Chemical tagging to identify the protein mediators of phytosterol anti-cancer activities A2003199 This project investigates how phytosterols—plant-derived fats found in seeds, nuts, and oils—interact with proteins in human breast cancer cells to slow tumour growth and enhance sensitivity to treatment. Although phytosterols show anti-cancer effects in lab studies, their precise molecular mechanisms remain poorly understood.Using a novel chemical tagging method that minimally affects phytosterol function, the research aims to identify the specific proteins phytosterols bind to in different breast cancer subtypes. Findings will clarify how phytosterols influence cancer pathways, potentially informing dietary recommendations and supporting future clinical trials. Lead Researcher Dr James ThorneAssociate professor of Cancer and Nutrition Co-Researchers Mr Baek Kim Dr Martin McPhillie Christopher Elvin Host Organisation University of Leeds Grant Amount £37,902.00 Start Date 01/10/2025 Estimated Duration 48 months Impact Areas Innovation & Health Technologies Tags/key notes Cancer and neoplasms Manage Cookie Preferences